Disposal of spent espresso coffee grounds (SCG) is costly and leads to the loss of bioactive compounds that could be fractionated, in several applications. This work aimed to investigate phenolic profile, tocopherols, and antioxidant and anti-proliferative activities of SCGs ethanolic extracts from coffee powders differing in coffee provenience and composition (arabica/robusta). Tyrosol, detected for the first time in SCGs, was the most abundant phenolic measured (121–1084 mg/kg in the extract), along with 4-hydroxybenzoic acid and vanillin (885–1813 and 340–1103 mg/kg, respectively). Extract derived from 100% robusta from Guatemala (S7-R) showed the highest α- to β-tocopherol ratio of 1.2 and the highest antioxidant potential as evidenced by RACI and GAS values of −0.43 and 0.20, respectively. Moreover, S7-R showed a promising anti-proliferative activity toward human lung carcinoma cells (A549), with IC₅₀ value of 61.2 μg/mL comparable to that given by the positive control vinblastine (IC₅₀ value of 67.3 μg/mL).

处置废弃的浓缩咖啡渣（SCG）的成本很高，并导致在某些应用中可能被分馏的生物活性化合物的损失。这项工作旨在调查咖啡来源和成分（阿拉伯/罗布斯塔）不同的咖啡粉中的SCG乙醇提取物的酚类，生育酚以及抗氧化剂和抗增殖活性。在SCG中首次检测到的酪醇是酚含量最高的提取物（提取物中的121–1084 mg / kg），以及4-羟基苯甲酸和香兰素（分别为885–1813和340–1103 mg / kg）。 。危地马拉（S7-R）的100％罗布斯塔提取物显示出最高的α-β-生育酚比为1.2，最高的抗氧化电位，其RACI和GAS值分别为-0.43和0.20。而且，₅₀值为61.2μg/ mL，与阳性对照长春花碱的值相当（IC ₅₀值为67.3μg/ mL）。