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Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues.
Developmental Cell ( IF 10.7 ) Pub Date : 2019-11-14 , DOI: 10.1016/j.devcel.2019.10.017 Pablo Sanchez Bosch 1 , Kalpana Makhijani 1 , Leire Herboso 1 , Katrina S Gold 1 , Rowan Baginsky 1 , Katie J Woodcock 2 , Brandy Alexander 1 , Katelyn Kukar 1 , Sean Corcoran 1 , Thea Jacobs 1 , Debra Ouyang 1 , Corinna Wong 1 , Elodie J V Ramond 3 , Christa Rhiner 4 , Eduardo Moreno 4 , Bruno Lemaitre 3 , Frederic Geissmann 5 , Katja Brückner 6
Developmental Cell ( IF 10.7 ) Pub Date : 2019-11-14 , DOI: 10.1016/j.devcel.2019.10.017 Pablo Sanchez Bosch 1 , Kalpana Makhijani 1 , Leire Herboso 1 , Katrina S Gold 1 , Rowan Baginsky 1 , Katie J Woodcock 2 , Brandy Alexander 1 , Katelyn Kukar 1 , Sean Corcoran 1 , Thea Jacobs 1 , Debra Ouyang 1 , Corinna Wong 1 , Elodie J V Ramond 3 , Christa Rhiner 4 , Eduardo Moreno 4 , Bruno Lemaitre 3 , Frederic Geissmann 5 , Katja Brückner 6
Affiliation
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The use of adult Drosophila melanogaster as a model for hematopoiesis or organismal immunity has been debated. Addressing this question, we identify an extensive reservoir of blood cells (hemocytes) at the respiratory epithelia (tracheal air sacs) of the thorax and head. Lineage tracing and functional analyses demonstrate that the majority of adult hemocytes are phagocytic macrophages (plasmatocytes) from the embryonic lineage that parallels vertebrate tissue macrophages. Surprisingly, we find no sign of adult hemocyte expansion. Instead, hemocytes play a role in relaying an innate immune response to the blood cell reservoir: through Imd signaling and the Jak/Stat pathway ligand Upd3, hemocytes act as sentinels of bacterial infection, inducing expression of the antimicrobial peptide Drosocin in respiratory epithelia and colocalizing fat body domains. Drosocin expression in turn promotes animal survival after infection. Our work identifies a multi-signal relay of organismal humoral immunity, establishing adult Drosophila as model for inter-organ immunity.
中文翻译：
成年果蝇缺乏造血功能，但依靠呼吸道上皮细胞的血细胞库将感染信号传递给周围组织。
使用成年果蝇作为造血或机体免疫模型一直存在争议。为了解决这个问题，我们在胸部和头部的呼吸道上皮（气管气囊）处发现了广泛的血细胞（血细胞）储存库。谱系追踪和功能分析表明，大多数成年血细胞是来自胚胎谱系的吞噬巨噬细胞（浆细胞），与脊椎动物组织巨噬细胞平行。令人惊讶的是，我们没有发现成人血细胞扩增的迹象。相反，血细胞在向血细胞库传递先天免疫反应方面发挥着作用：通过 Imd 信号传导和 Jak/Stat 通路配体 Upd3，血细胞充当细菌感染的哨兵，诱导呼吸道上皮中抗菌肽 Drosocin 的表达并共定位脂肪体域。 Drosocin 的表达反过来又促进动物感染后的存活。我们的工作确定了机体体液免疫的多信号传递，将成年果蝇建立为器官间免疫的模型。
更新日期：2019-11-14
中文翻译：
成年果蝇缺乏造血功能，但依靠呼吸道上皮细胞的血细胞库将感染信号传递给周围组织。
使用成年果蝇作为造血或机体免疫模型一直存在争议。为了解决这个问题，我们在胸部和头部的呼吸道上皮（气管气囊）处发现了广泛的血细胞（血细胞）储存库。谱系追踪和功能分析表明，大多数成年血细胞是来自胚胎谱系的吞噬巨噬细胞（浆细胞），与脊椎动物组织巨噬细胞平行。令人惊讶的是，我们没有发现成人血细胞扩增的迹象。相反，血细胞在向血细胞库传递先天免疫反应方面发挥着作用：通过 Imd 信号传导和 Jak/Stat 通路配体 Upd3，血细胞充当细菌感染的哨兵，诱导呼吸道上皮中抗菌肽 Drosocin 的表达并共定位脂肪体域。 Drosocin 的表达反过来又促进动物感染后的存活。我们的工作确定了机体体液免疫的多信号传递，将成年果蝇建立为器官间免疫的模型。
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