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KRAS-G12C in the crosshairs.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41568-019-0228-3
Sarah Seton-Rogers 1
Affiliation  

Two papers report the discovery and preclinical analyses of two different covalent inhibitors of KRAS-G12C (AMG 510 and MRTX849) as well as the first data on the efficacy of these inhibitors in cancer patients.

中文翻译:

十字准线中的KRAS-G12C。

有两篇论文报道了两种不同的KRAS-G12C共价抑制剂(AMG 510和MRTX849)的发现和临床前分析,以及有关这些抑制剂在癌症患者中疗效的首批数据。
更新日期:2019-11-14
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