The mycobacterial cell envelope - a moving target.,Nature Reviews Microbiology

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The mycobacterial cell envelope - a moving target.
Nature Reviews Microbiology ( IF 69.2 ) Pub Date : 2019-11-14 , DOI: 10.1038/s41579-019-0273-7
Charles L Dulberger _{1,

2} , Eric J Rubin _{2,

3} , Cara C Boutte ₄

Affiliation

Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and immunomodulatory cell envelope. The cell envelope structurally and functionally varies across the length of the cell and during the infection process. This variability allows the bacterium to manipulate the human immune system, tolerate antibiotic treatment and adapt to the variable host environment. Much of what we know about the mycobacterial cell envelope has been gleaned from model actinobacterial species, or model conditions such as growth in vitro, in macrophages and in the mouse. In this Review, we combine data from different experimental systems to build a model of the dynamics of the mycobacterial cell envelope across space and time. We describe the regulatory pathways that control metabolism of the cell wall and surface lipids in M. tuberculosis during growth and stasis, and speculate about how this regulation might affect antibiotic susceptibility and interactions with the immune system.

中文翻译：

分枝杆菌细胞包膜-移动目标。

结核分枝杆菌是感染导致死亡的主要原因，它具有动态的免疫调节细胞膜。细胞包膜在整个细胞长度上以及在感染过程中在结构和功能上都不同。这种可变性使细菌能够操纵人类的免疫系统，耐受抗生素治疗并适应可变的宿主环境。我们对分枝杆菌细胞包膜的了解大多来自模型放线菌物种或模型条件，例如体外，巨噬细胞和小鼠中的生长。在这篇综述中，我们结合了来自不同实验系统的数据，建立了分枝杆菌细胞包膜跨时空动态的模型。我们描述了控制M细胞壁和表面脂质代谢的调控途径。

更新日期：2019-11-14

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