INTRODUCTION Methylphenidate (Ritalin) is a CNS stimulant, and is a common treatment for children and adults with ADHD. It has been associated with Raynaud's phenomenon (RP) but not with Systemic Sclerosis (SSc). We report a case series of patients pointing out the connection between Methylphenidate and SSc. CASES We identified three patients in a single Rheumatology clinic in Israel, who developed SSc following treatment with CNS stimulants for ADHD. All three cases had Raynaud's phenomenon, skin changes, pathological capillaroscopy and positive ANA. Symptoms appeared and worsened over months following the use of methylphenidate and subsided after its cessation. CONCLUSION This is the first report in the literature of a causative relation between methylphenidate and the development of SSc, a serious, life-threatening condition. Patients treated with CNS stimulants should be followed closely for side-effects such as RP and skin changes.

中文翻译：

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中枢神经系统兴奋剂引起的多动症引起的系统性硬化症：一个病例系列和文献综述。

简介哌醋甲酯（利他林）是一种中枢神经系统兴奋剂，是多动症儿童和成人的常见治疗方法。它与雷诺现象（RP）有关，但与系统性硬化症（SSc）不相关。我们报告了一系列病例，指出了哌醋甲酯与SSc之间的联系。案例我们在以色列的一家风湿病诊所中鉴定出三名患者，这些患者在接受中枢神经系统兴奋剂治疗多动症后发展为SSc。三例均出现雷诺现象，皮肤改变，病理性毛细血管镜检查和阳性ANA。使用哌醋甲酯后数月出现症状并加重症状，停药后症状减轻。结论这是文献首次报道哌醋甲酯与SSc的发展之间存在因果关系，SSc是一种严重的威胁生命的疾病。