PURPOSE AIDs may disproportionately impact specific racial groups, but autoimmune (AID) prevalence information by minority racial group is sparse for many AIDs. The objective of this analysis was to supplement previously published AID prevalence rates by providing information on race rate ratios (minority race populations compared to Caucasian populations) in the United States. Preliminary to estimating race rate ratios, contemporary US-specific, health care utilization-based AID prevalence rates and female-to-male ratios were estimated and compared to previously published AID prevalence rates. METHODS We used a large national electronic medical record database of 52 million individuals to estimate age-adjusted direct standardized rates for 22 AIDs for 2010 through 2016 by gender, race, and US census division. These were compared to previously published estimates. RESULTS Female-to-male ratios were comparable with published studies. Almost all observed Multiracial AID rates were significantly higher than Caucasian rates, as well as 9 of 22 AID rates observed among Native Americans and 8 of 22 AID rates estimated among African-American patients. Regional variation was noted: highest African-American systemic lupus erythematosus rates were observed in the West North Central and South Atlantic divisions, highest African-American multiple sclerosis rates in the South Atlantic and Pacific divisions, and highest Native American rheumatoid arthritis rates in the West North Central, Mountain, and Pacific divisions. CONCLUSIONS Substantial AID heterogeneity exists by race and by geographic area. An important research area is further exploring factors related to heterogeneity such as potential interactions between genetic susceptibility and environmental factors.

中文翻译：

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2010-2016 年美国自身免疫性疾病发病率比较（按性别、地理区域和种族划分）。


有目的的艾滋病可能会对特定种族群体产生不成比例的影响，但对于许多艾滋病而言，少数种族群体的自身免疫 (AID) 患病率信息很少。该分析的目的是通过提供美国种族比率（少数族裔人口与白种人人口相比）的信息来补充之前公布的 AID 患病率。在初步估计种族率比率时，估计了当代美国特定的、基于医疗保健利用的 AID 患病率和女性与男性的比率，并与之前公布的 AID 患病率进行比较。方法 我们使用包含 5200 万人的大型国家电子病历数据库，按性别、种族和美国人口普查部门估算 2010 年至 2016 年 22 种艾滋病的年龄调整直接标准化发病率。这些数据与之前发布的估计值进行了比较。结果 女性与男性的比例与已发表的研究相当。几乎所有观察到的多种族 AID 率均显着高于白人，在美洲原住民中观察到的 22 个 AID 率中有 9 个，在非洲裔美国患者中估计的 22 个 AID 率中有 8 个。注意到区域差异：非洲裔美国人系统性红斑狼疮发病率最高的是中西北部和南大西洋地区，非洲裔美国人多发性硬化症发病率最高的是南大西洋和太平洋地区，美洲原住民类风湿性关节炎发病率最高的是西部地区中北部、山区和太平洋分区。结论 不同种族和不同地理区域的援助存在显着异质性。一个重要的研究领域是进一步探索与异质性相关的因素，例如遗传易感性和环境因素之间的潜在相互作用。