T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).

中文翻译：

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TCF-1控制淋巴细胞命运，感染和肿瘤免疫。

由Tcf7编码的T细胞因子-1（TCF-1）是转录因子和组蛋白脱乙酰基酶（HDAC），对哺乳动物的T细胞和先天性淋巴样细胞（ILC）谱系都有重要作用。在这篇综述中，我们讨论了TCF-1在建立这些谱系中的多功能作用，以及整个谱系分化和维持谱系稳定性对TCF-1的要求。我们重点介绍了最近的报道，这些报道表明TCF-1有望作为一种新型生物标志物来鉴定疲惫的CD8 + T细胞的近期特征性亚型，这可能有助于预测患者对免疫检查点封锁（ICB）的反应。