Mammalian group 2 innate lymphoid cells (ILC2s) are responsible for the early production of type 2 cytokines at mucosal barriers upon exposure to allergen. Inflammatory tissue environmental cues can influence ILC2 activity, and this cellular population can be further categorized into subtypes with additional or alternative functions. Subtypes can include trained (or 'memory-like') ILC2s, which recall previous allergic inflammation, inflammatory ILC2s, which acquire the ability to produce IL-17, and ex-ILC2s, which produce ILC1 cytokines. However, the functional states of ILC2s at sites of chronic or severe inflammation are not well characterized. Here, we discuss the emergence of ILC2s with 'exhausted'-like signatures, and argue that their hyporesponsiveness to stimulation and expression of inhibitory receptors is relevant in mammalian chronic allergic inflammation.

中文翻译：

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慢性过敏性炎症中的疲惫样第2组先天淋巴样细胞。

哺乳动物第2组先天淋巴样细胞（ILC2）负责在暴露于过敏原后在粘膜屏障处早期产生2型细胞因子。炎性组织环境提示可能会影响ILC2活性，并且该细胞群体可以进一步分为具有其他功能或替代功能的亚型。亚型可以包括受过训练的（或“类似记忆”的）ILC2（可回忆起以前的过敏性炎症），发炎的ILC2（可产生IL-17的能力）和ex-ILC2（可产生ILC1细胞因子）。但是，ILC2s在慢性或严重炎症部位的功能状态尚未很好地表征。在这里，我们讨论带有“精疲力竭”样签名的ILC2的出现，