Lipid mechanisms in hallmarks of cancer.,Molecular Omics

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Lipid mechanisms in hallmarks of cancer.
Molecular Omics ( IF 3.0 ) Pub Date : 2019-11-14 , DOI: 10.1039/c9mo00128j
J Molendijk ₁ , H Robinson , Z Djuric , M M Hill

Affiliation

Excess adiposity is a risk factor for several cancer types. This is likely due to complex mechanisms including alterations in the lipid milieu that plays a pivotal role in multiple aspects of carcinogenesis. Here we consider the direct role of lipids in regulating well-known hallmarks of cancer. Furthermore, we suggest that obesity-associated remodelling of membranes and organelles drives cancer cell proliferation and invasion. Identification of cancer-related lipid-mediated mechanisms amongst the broad metabolic disturbances due to excess adiposity is central to the identification of novel and more efficacious prevention and intervention strategies.

中文翻译：

癌症标志中的脂质机制。

过度肥胖是多种癌症的危险因素。这可能是由于复杂的机制，包括在致癌作用的多个方面发挥关键作用的脂质环境的改变。在这里，我们考虑脂质在调节众所周知的癌症特征中的直接作用。此外，我们认为与肥胖相关的细胞膜和细胞器重塑会驱动癌细胞增殖和侵袭。在过度肥胖引起的广泛代谢紊乱中识别与癌症相关的脂质介导机制对于识别新颖且更有效的预防和干预策略至关重要。

更新日期：2019-11-14

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