Halogen-Radical-Promoted Dearomative Aza-Spirocyclization of Alkynylimines: An Efficient Approach to 3-Halo-Spirocyclohexadienones,Synthesis

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Halogen-Radical-Promoted Dearomative Aza-Spirocyclization of Alkynylimines: An Efficient Approach to 3-Halo-Spirocyclohexadienones
Synthesis ( IF 2.2 ) Pub Date : 2019-11-13 , DOI: 10.1055/s-0039-1690746
Dianpeng Chen ₁ , Jianming Li ₁ , Yingying Shan ₁ , Peiying Cui ₁ , Yutong Zhao ₁ , Laijin Tian ₁ , Guanyinsheng Qiu _{2,

3}

Affiliation

A novel halogen-radical-promoted dearomative aza-spirocyclization of alkynylimines for the synthesis of 3-halo-spirocyclohexadienones is described. In this process, it is believed that a radical addition, 5-exo-trig cyclization, and dearomative aza-spirocyclization are involved. Easily available starting materials, mild conditions, and a wide substrate scope make this approach potentially useful.

中文翻译：

卤素自由基促进的炔丙胺脱氮脱氮氮杂螺环化：3-卤代螺环己二酮的有效方法

描述了用于合成3-卤代-螺环己二酮的新型炔烃的卤素自由基促进的脱芳香基氮杂-螺环化。在该过程中，据信涉及自由基加成，5- exo - trig环化和脱芳香性氮杂-螺环化。容易获得的起始原料，温和的条件以及广泛的底物范围使该方法具有潜在的实用性。

更新日期：2019-11-14

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