Hydroalkylation of Unactivated Alkenes with Ketones and 5-Benzylfurfurals Enabled by Amine/Pd(II) Cooperative Catalysis,Synthesis

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Hydroalkylation of Unactivated Alkenes with Ketones and 5-Benzylfurfurals Enabled by Amine/Pd(II) Cooperative Catalysis
Synthesis ( IF 2.2 ) Pub Date : 2019-11-13 , DOI: 10.1055/s-0039-1690245
Mostafa Sayed _{1,

2} , Hong-Cheng Shen ₁ , Ling Zhang ₁ , Liu-Zhu Gong _{1,

3}

Affiliation

An intermolecular addition of ketones to unactivated alkenes has been developed by means of Pd(II)/amine cooperative catalysis, which incorporates the simultaneous activation of amide-containing alkenes and α-carbon of ketones enabled by Pd(II) catalyst and enamine, respectively. Moreover, the addition of 5-benzylfurfural derivatives to an unactivated alkene has also been achieved by integrating Pd(II) and trienamine catalysis to provide γ-adducts at the benzylic position of furfurals in good to high yields.

中文翻译：

胺/ Pd（II）协同催化的酮和5-苄基糠醛对未活化烯烃的加氢烷基化

通过Pd（II）/胺协同催化开发了将酮分子间加成到未活化的烯烃上的方法，该催化结合了分别由Pd（II）催化剂和烯胺使含酰胺的烯烃和酮的α-碳同时活化的方法。。此外，还通过整合Pd（II）和三烯胺催化以在糠醛的苄基位置上以高至高收率提供γ-加合物来实现将5-苄基糠醛衍生物加至未活化的烯烃中。

更新日期：2019-11-14

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