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Salen‑manganese complexes for controlling ROS damage: Neuroprotective effects, antioxidant activity and kinetic studies.
Journal of Inorganic Biochemistry ( IF 3.8 ) Pub Date : 2019-11-14 , DOI: 10.1016/j.jinorgbio.2019.110918
Lara Rouco 1 , Andrea Liberato 2 , M Jesús Fernández-Trujillo 2 , Angeles Máñez 2 , Manuel G Basallote 2 , Rebeca Alvariño 3 , Amparo Alfonso 3 , Luis M Botana 3 , Marcelino Maneiro 1
Affiliation  

A new manganese(III) complex [MnL1(DCA)(H2O)](H2O),1 [H2L1 is the chelating ligand N,N'-bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminopropane, and DCA is dicyanamide], has been prepared and characterized by different analytical and spectroscopic techniques. The tetragonally elongated octahedral geometry for the manganese coordination sphere was revealed by X-ray diffraction studies for 1. The antioxidant behavior of this complex and other manganese(III)-salen type complexes was tested through superoxide dismutase and catalase probes, and through the study of their neuroprotective effects in SH-SY5Y neuroblastoma cells. In this human neuronal model, these model complexes were found to improve cell survival in an oxidative stress model. During studies aimed to getting a better understanding of the kinetics of the processes involved in this antioxidant behavior, an important effect on the solvent in the kinetics of reaction of the complexes with H2O2 was revealed that suggests a change in the mechanism of reaction of the complexes. The kinetic data in methanol and buffered aqueous solutions correlate well with the results of the test of catalase activity, thus showing that the rate determining step in the catalytic cycle corresponds to the initial reaction of the complexes with H2O2.

中文翻译:

Salen-锰配合物,用于控制ROS损伤:神经保护作用,抗氧化剂活性和动力学研究。

一种新的锰(III)配合物[MnL1(DCA)(H2O)](H2O),1 [H2L1是螯合配体N,N'-双(2-羟基-3-甲氧基亚苄基)-1,2-二氨基丙烷,和DCA是双氰胺],已通过不同的分析和光谱技术制备和表征。通过1的X射线衍射研究揭示了锰配位球的四边形八面体几何形状。通过超氧化物歧化酶和过氧化氢酶探针以及该研究测试了该配合物和其他锰(III)-salen型配合物的抗氧化性能。在SH-SY5Y神经母细胞瘤细胞中的神经保护作用 在此人类神经元模型中,发现这些模型复合物可改善氧化应激模型中的细胞存活率。在旨在更好地了解该抗氧化剂行为的过程动力学的研究过程中,发现了配合物与H2O2的反应动力学中对溶剂的重要影响,这表明配合物的反应机理发生了变化。 。甲醇和缓冲水溶液中的动力学数据与过氧化氢酶活性的测试结果密切相关,因此表明催化循环中的速率确定步骤与配合物与H2O2的初始反应相对应。
更新日期:2019-11-14
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