To the Editor We read with much interest the Original Investigation by Banerjee et al.¹ The authors found that accumulated anesthesia exposures may be associated with poor neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia (ALL). The authors suggested that anesthesia exposures should be limited in pediatric patients with chronic health conditions who undergo multiple medical procedures. Given that millions of children worldwide receive anesthesia and sedation for various purposes, the study results and implications may raise important public health concerns. We wish to highlight some important limitations in the methods used to estimate associations between anesthesia exposures and neurocognitive outcomes.

致编辑我们非常感兴趣地阅读了 Banerjee 等人的原始调查。¹作者发现，累积的麻醉暴露可能与儿童急性淋巴细胞白血病 (ALL) 长期幸存者的神经认知结果不佳有关。作者建议，对于接受多种医疗程序的患有慢性健康状况的儿科患者，应限制麻醉暴露。鉴于全球数百万儿童因各种目的接受麻醉和镇静，研究结果和影响可能会引发重要的公共卫生问题。我们希望强调用于估计麻醉暴露与神经认知结果之间关联的方法中的一些重要限制。