Polyphosphazenes for the delivery of biopharmaceuticals,Journal of Applied Polymer Science

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Polyphosphazenes for the delivery of biopharmaceuticals
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2019-11-14 , DOI: 10.1002/app.48688
Wei‐Hsin Hsu _{1,

2} , Noemi Csaba ₁ , Cameron Alexander ₂ , Marcos Garcia‐Fuentes ₁

Affiliation

Polyphosphazenes (PPZs) are a relatively new family of polymers based on a nitrogen–phosphorous backbone where organic side groups can be grafted. The synthetic route to PPZs is highly versatile such that it is possible to add many different functionalities that change completely the physicochemical and biological properties of the polymers. For instance, PPZs can be designed with a variety of organic side groups that render these materials biodegradable and highly biocompatible. Based on these positive features, PPZs have been explored for many biomedical applications including the design of numerous advanced drug delivery systems. In this area, PPZs have been particularly investigated as materials for the formulation of biopharmaceuticals of high added value. These include protein‐ and polynucleotide‐based medicines, applications where PPZ carriers have obtained very positive results in preclinical models. A further area of major interest for PPZs has been vaccination, where these materials have obtained excellent results in vivo as polymer adjuvants and have advanced to clinical evaluation. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48688.

中文翻译：

聚磷腈用于生物药物的输送

聚磷腈（PPZ）是一个相对较新的聚合物家族，其基于氮-磷主链，可以在其中接枝有机侧基。合成PPZ的途径非常通用，因此可以添加许多不同的功能，从而完全改变聚合物的物理化学和生物学特性。例如，PPZ可以设计成具有多种有机侧基，从而使这些材料具有生物降解性和高度生物相容性。基于这些积极特性，PPZ已经在许多生物医学应用中得到了探索，包括设计了许多先进的药物输送系统。在这一领域，已经对PPZs作了特别研究，以作为高附加值生物药物制剂的原料。这些包括基于蛋白质和多核苷酸的药物，PPZ载体在临床前模型中获得了非常积极的结果的应用。疫苗接种的另一个主要领域是疫苗接种，这些材料在疫苗接种中获得了出色的效果在体内作为聚合物佐剂并已用于临床评估。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学 2020，137，48688。

更新日期：2020-03-26

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