LCMV-specific CD4 T cell dependent polyclonal B-cell activation upon persistent viral infection is short lived and extrafollicular.,European Journal of Immunology

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LCMV-specific CD4 T cell dependent polyclonal B-cell activation upon persistent viral infection is short lived and extrafollicular.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2019-11-27 , DOI: 10.1002/eji.201948286
Ute Greczmiel ₁ , Nike J Kräutler ₁ , Mariana Borsa ₁ , Alessandro Pedrioli ₁ , Ilka Bartsch ₁ , Kirsten Richter ₁ , Paola Agnellini ₁ , Gregor Bedenikovic ₁ , Annette Oxenius ₁

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Persistent virus infections with non- or poorly cytopathic viruses are commonly associated with B cell dysregulations. These include the induction of hypergammaglobulinemia and the emergence of virus-unspecific antibodies. These seemingly unspecific antibody responses interfere with the virus-specific humoral immunity and contribute to delayed virus control. Whether these virus-unspecific antibodies are induced in the B cell follicle or at extrafollicular sites and whether one specific CD4 T cell subset is involved in the polyclonal B cell activation is unclear. Here we studied virus-unrelated IgG antibody responses against self or foreign antigens in the context of persistent lymphocytic choriomeningitis virus (LCMV) infection. We found that the LCMV-unspecific antibody response is short-lived and induced predominantly at extrafollicular sites and depends on the presence of LCMV-specific CD4 T cells. Our data support a scenario in which activated, virus-specific CD4 T cells provide help to non-specific B cells at extrafollicular sites, supporting the production of virus unspecific IgG antibodies during persistent viral infection.

中文翻译：

持续性病毒感染后，LCMV特异的CD4 T细胞依赖性多克隆B细胞活化是短暂的，是细胞外的。

非致病性或致病性差的病毒的持续性病毒感染通常与B细胞功能失调有关。这些包括高球蛋白血症的诱导和病毒非特异性抗体的出现。这些看似非特异性的抗体反应会干扰病毒特异性的体液免疫，并导致延迟的病毒控制。尚不清楚这些病毒非特异性抗体是在B细胞卵泡中还是在卵泡外部位被诱导，以及多克隆B细胞活化是否涉及一种特定的CD4 T细胞亚群。在这里，我们研究了在持续性淋巴细胞脉络膜脑膜炎病毒（LCMV）感染的情况下针对自身或外来抗原的病毒无关IgG抗体应答。我们发现，LCMV非特异性抗体应答是短暂的，主要在卵泡外部位引起，并且取决于LCMV特异性CD4 T细胞的存在。我们的数据支持一种方案，在这种方案中，活化的病毒特异性CD4 T细胞可为细胞外部位的非特异性B细胞提供帮助，从而支持在持续性病毒感染期间产生病毒非特异性IgG抗体。

更新日期：2019-11-28

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