Mice lacking CD4+ T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.

中文翻译：

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NF-κB转录因子c-Rel控制宿主对啮齿类柠檬酸杆菌的防御。

缺乏CD4 + T细胞或B细胞的小鼠极易感染啮齿类柠檬酸杆菌。在这项研究中，我们表明淋巴细胞中转录因子c-Rel的活性对于清除啮齿类梭状芽胞杆菌至关重要。缺乏c-Rel的小鼠无法产生保护性抗体并无法消灭病原体。