Structural Modification Orientated Multifunctional AIE Fluorescence Probes: Organelles Imaging and Effective Photosensitizer for Photodynamic Therapy,Advanced Optical Materials

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Structural Modification Orientated Multifunctional AIE Fluorescence Probes: Organelles Imaging and Effective Photosensitizer for Photodynamic Therapy
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2019-11-13 , DOI: 10.1002/adom.201901433
Kongqi Chen ₁ , Rongyuan Zhang ₂ , Zhiming Wang _{1,

3} , Weijie Zhang _{2,

3,

4} , Ben Zhong Tang _{1,

3,

4}

Affiliation

Luminogens with aggregation‐induced emission feature (AIEgens) are highly demanded because of its excellent performance in fluorescent bioprobes. In this work, three AIEgens based on tetraphenylethylene isoquinolinium (TPE‐IQ) derivatives by introducing different electron donor and sterically hindered groups to replace the phenyl ring of the isoquinolinium core are prepared in a one‐pot reaction with a high yield and characterized systematically. By the analysis of photophysical properties and theoretical calculations, the structure‐property relationships among them become clear. Although they all inherit AIE feature as expected, these similar structural AIEgens present different organelle‐targets, which is attributed to their different cellular uptake way and energy barrier to cell membrane by detailed experiments. In addition, these TPE‐IQ‐based AIEgens are potential candidates for photodynamic therapy originating from their activities of generating reactive oxygen species under visible light irradiation.

中文翻译：

面向结构修饰的多功能AIE荧光探针：细胞器成像和用于光动力疗法的有效光敏剂

由于其在荧光生物探针中的优异性能，对具有聚集诱导发射特征的发光剂（AIEgens）提出了很高的要求。在这项工作中，通过引入不同的电子供体和空间位阻基团取代异喹啉鎓核心的苯环，以高收率制备了三种基于四苯基乙烯异喹啉鎓（TPE-IQ）衍生物的AIEgen，并进行了系统表征。通过光物理性质的分析和理论计算，它们之间的结构-性质关系变得清晰。尽管它们都继承了预期的AIE功能，但这些相似的结构AIEgens呈现出不同的细胞器靶标，这是由于详细的实验，它们具有不同的细胞吸收方式和对细胞膜的能量屏障。此外，

更新日期：2020-01-17

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