BACKGROUND Exercise therapy is becoming extremely relevant as a new efficacious intervention in multiple medical fields. Although several clinical trials have reported benefits of exercise therapy for Parkinson's disease (PD), recommendations and prescriptions for its use in clinical practice remain limited. OBJECTIVES To evaluate the methodological quality and publication rate of clinical trials on exercise therapy for PD. METHODS We analyzed all clinical trials assessing exercise therapy for PD registered in the WHO International Clinical Trials Registry Platform and the ClinicalTrials.gov registries, from 2000 to 2017. We evaluated the methodological quality of trials using the Cochrane Risk of Bias criteria. RESULTS A total of 236 clinical trials were identified. Only 70 (29.7%) trials reported their findings, and 61 (25.8%) had results published in scientific journals. Most trials had an unclear risk of bias concerning incomplete and selective outcome reporting and lacked data on the randomization process, allocation concealment, blinding of participants and personnel, and outcomes assessors. Aerobic capacity was the most frequent type of exercise intervention. CONCLUSIONS Although a large number of trials on exercise are registered in international portals, the quality of reporting remains suboptimal and only a quarter of trials have their results published in scientific journals. These two factors, in addition to the heterogeneity of the interventions tested and the unsatisfactory reported methodological quality of most trials, compromise the interpretation of study results. Therefore, higher quality clinical trials reports are needed to establish exercise as part of the PD armamentarium.

中文翻译：

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帕金森氏病运动疗法临床试验的报告和方法学质量。

背景技术作为在多个医学领域中的新的有效干预手段，运动疗法正变得极为相关。尽管一些临床试验报告了运动疗法对帕金森氏病（PD）的益处，但在临床实践中使用该疗法的建议和处方仍然很有限。目的评估运动疗法治疗PD的方法学质量和临床试验的发表率。方法我们分析了2000年至2017年在WHO国际临床试验注册平台和ClinicalTrials.gov注册表中注册的评估PD运动疗法的所有临床试验。我们使用Cochrane偏倚风险标准评估了试验的方法学质量。结果总共鉴定了236项临床试验。只有70（29.7％）个试验报告了他们的发现，还有61个（25。8％）的结果发表在科学期刊上。大多数试验对于不完整和选择性的结果报告存在偏见风险，并且缺乏关于随机化过程，分配隐藏，参与者和人员盲目以及结果评估者的数据。有氧运动能力是最常见的运动干预类型。结论尽管在国际门户网站上注册了大量的运动试验，但是报告的质量仍然欠佳，只有四分之一的试验结果在科学期刊上发表。除了测试的干预措施的异质性和大多数试验报告的方法学质量不令人满意外，这两个因素还影响了研究结果的解释。所以，