PfEMP1 is the major surface antigen of P. falciparum-infected erythrocytes, mediates endothelial adhesion, and displays extreme sequence diversity that underpins antigenic variation. In this issue of Cell Host & Microbe, Tessema et al. (2019) find that antibodies in sera from a pediatric cohort that bind a discrete PfEMP1 subset associate with protection from severe malaria and predict future risk.

中文翻译：

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对严重疟疾的免疫力：PfEMP1 标签讲述一个故事

PfEMP1 是恶性疟原虫感染的红细胞的主要表面抗原，介导内皮粘附，并表现出支持抗原变异的极端序列多样性。在本期《细胞宿主与微生物》中，Tessema 等人。 (2019) 发现儿科队列血清中的抗体与离散的 PfEMP1 子集结合，与预防严重疟疾并预测未来风险相关。