Self-complementary supramolecular polymers (SCSPs), an efficient combination of sextuple hydrogen-bonded dimer moieties and a temperature-responsive polymer, can promote the construction of stable supramolecular polymer networks (SPNs) that enable the formation of well-defined nanospherical micelles in aliphatic alcohols. These micelles undergo tailorable, thermoresponsive phase transitions at the upper critical solution temperature (UCST) and have a desirable spherical morphology and size ranges, thus, are potential candidates for applications in interfacial engineering and biomedical fields. Moreover, concentration-dependent UCST measurements and variable-temperature experiments indicated that the hydrogen-bonded complexes are strong enough to form stable intermolecularly entangled SPNs within the micelles, even above the UCST or at low concentrations in solution, which enables the micelles to undergo reversible temperature-dependent conformational changes between insoluble and soluble globules without significant changes in particle size or size distribution. Thus, this newly discovered system offers a new approach toward the development of next-generation temperature-responsive SCSPs with the desired structural stability that undergoes UCST transitions.

中文翻译：

---

脂肪醇中聚合物胶束内超分子聚合物网络介导的结构相变

自互补超分子聚合物 (SCSPs) 是六重氢键二聚体部分和温度响应性聚合物的有效组合，可以促进稳定的超分子聚合物网络 (SPNs) 的构建，从而在脂肪族中形成定义明确的纳米球形胶束酒精。这些胶束在上限临界溶解温度 (UCST) 下经历可定制的热响应相变，并具有理想的球形形态和尺寸范围，因此是界面工程和生物医学领域应用的潜在候选者。此外，依赖于浓度的 UCST 测量和变温实验表明，氢键复合物的强度足以在胶束内形成稳定的分子间纠缠的 SPN，甚至高于 UCST 或溶液中的低浓度，这使得胶束能够在不溶性和可溶性小球之间经历可逆的温度依赖性构象变化，而不会显着改变粒径或尺寸分布。因此，这个新发现的系统为开发下一代温度响应 SCSPs 提供了一种新方法，该 SCSPs 具有经历 UCST 转变的所需结构稳定性。