Impact of HIV-1 viremia or sexually transmitted infection on semen-derived anti-HIV-1 antibodies and the immunosuppressive capacity of seminal plasma.,European Journal of Immunology

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Impact of HIV-1 viremia or sexually transmitted infection on semen-derived anti-HIV-1 antibodies and the immunosuppressive capacity of seminal plasma.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2019-11-13 , DOI: 10.1002/eji.201848055
Kevin J Selva ₁ , Benjamin R Bavinton ₂ , Andrew E Grulich ₂ , Marzena Pazgier ₃ , Anthony D Kelleher ₂ , Stephen J Kent _{1,

4,

5} , Matthew S Parsons _{1,

6,

7}

Affiliation

Semen from HIV-1-infected men contains anti-HIV-1 antibodies and immunosuppressive factor(s). We assessed if suppression of viremia with antiretroviral therapy impacted seminal plasma immunosuppressive capacity or the Fc-dependent functions of seminal anti-HIV-1 antibodies. We also tested if active bacterial sexually transmitted infections altered the immunosuppressive capacity of seminal plasma.

中文翻译：

HIV-1病毒血症或性传播感染对精液来源的抗HIV-1抗体的影响以及精浆的免疫抑制能力。

来自HIV-1感染男性的精液含有抗HIV-1抗体和免疫抑制因子。我们评估了抗逆转录病毒疗法对病毒血症的抑制作用是否影响了精浆血浆免疫抑制能力或精浆抗HIV-1抗体的Fc依赖性功能。我们还测试了活跃的细菌性传播感染是否改变了精浆的免疫抑制能力。

更新日期：2019-11-13

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