We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.

中文翻译：

---

从携带家族突变的帕金森氏病患者中产生八种人类诱导的多能干细胞系。

我们使用非整合型游离质粒从具有不同家族突变的帕金森氏病（PD）患者中产生了8条诱导性多能干细胞（iPSC）系。所有iPSC品系均具有正常的核型，表达多能性基因（包括POU5F1，NANOG），并显示碱性磷酸酶活性以及分化为所有三个胚层的能力。这些PD iPSC品系可用于疾病建模，以识别PD机制，以及用于新药的开发或分层。