Electrospinning, as an effective method for preparation of scaffolds for cell growth templates, has attracted great attention. In this study electrospinning was used to prepare poly (vinyl alcohol) (PVA)/chitosan scaffolds for bone tissue engineering. In order to improve the bioactivity and mechanical properties of the fibrous scaffolds, 0.5, 1 and 2 wt% akermanite, a calcium silicate based bioceramic, was added to the electrospinning solution. The morphology of the electrospun scaffolds was observed by using field emission-scanning electron microscopy and their mechanical strengths were analyzed by tension tests. The results showed that the formed scaffolds consisted of fibers with less than 100 nm diameter. In the case of the composite containing 1 wt% akermanite, the fibers were more homogeneous and no beads were formed during electrospinning, while in the composite containing 2 wt% akermanite a considerable number of beads were formed which we attribute to an improper viscosity of the electrospinning solution. Among the different compositions, the composite containing 1 wt% akermanite showed higher ultimate tensile strength (10.6 MPa) and fracture strain (9%). These values were increased by crosslinking the scaffold by reaction with glutaraldehyde, up to 13 MPa and 9.4%, respectively.

作为制备细胞生长模板支架的有效方法，静电纺丝已引起了极大的关注。在这项研究中，静电纺丝用于制备用于骨组织工程的聚乙烯醇（PVA）/壳聚糖支架。为了改善纤维状支架的生物活性和机械性能，将0.5、1和2重量％的硅酸钙（基于硅酸钙的生物陶瓷）添加到电纺丝溶液中。使用场发射扫描电子显微镜观察电纺支架的形态，并通过拉伸试验分析其机械强度。结果表明，形成的支架由直径小于100 nm的纤维组成。在复合材料包含1 wt％的钙锰矿的情况下，纤维更均匀，在静电纺丝过程中不会形成任何珠，而在含有2 wt％钙钛矿的复合材料中，形成了大量的珠，这归因于电纺丝溶液的粘度不当。在不同的组成中，含1wt％钙钛矿的复合材料显示出更高的极限抗拉强度（10.6 MPa）和断裂应变（9％）。这些值通过与戊二醛反应使支架交联而增加，分别高达13 MPa和9.4％。