Polymer nanocarriers for MicroRNA delivery,Journal of Applied Polymer Science

当前位置： X-MOL 学术 › J. Appl. Polym. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Polymer nanocarriers for MicroRNA delivery
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2019-11-12 , DOI: 10.1002/app.48651
Chintan H Kapadia ₁ , Benjamin Luo ₁ , Megan N Dang ₁ , N'Dea Irvin-Choy ₁ , Danielle M Valcourt ₁ , Emily S Day _{1,

2,

3}

Affiliation

Abnormal expression of microRNAs (miRNAs), which are highlyconserved noncoding RNAs that regulate the expression of various genes post transcriptionally to control cellular functions, has been associated with the development of many diseases. In some cases, disease‐promoting miRNAs are upregulated, while in other instances disease‐suppressive miRNAs are downregulated. To alleviate this imbalanced miRNA expression, either antagomiRs or miRNA mimics can be delivered to cells to inhibit or promote miRNA expression, respectively. Unfortunately, the clinical translation of bare antagomiRs and miRNA mimics has been challenging because nucleic acids are susceptible to nuclease degradation, display unfavorable pharmacokinetics, and cannot passively enter cells. This review emphasizes the challenges associated with miRNA mimic delivery and then discusses the design and implementation of polymer nanocarriers to overcome these challenges. Preclinical efforts are summarized, and a forward‐looking perspective on the future clinical translation of polymer nanomaterials as miRNA delivery vehicles is provided. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48651.

中文翻译：

用于 MicroRNA 递送的聚合物纳米载体

microRNA (miRNA) 是高度保守的非编码 RNA，可在转录后调节各种基因的表达以控制细胞功能，其异常表达与许多疾病的发生有关。在某些情况下，促进疾病的 miRNA 上调，而在其他情况下，抑制疾病的 miRNA 下调。为了缓解这种不平衡的 miRNA 表达，可以将 antagomiR 或 miRNA 模拟物递送到细胞中，分别抑制或促进 miRNA 表达。不幸的是，裸露的 antagomiR 和 miRNA 模拟物的临床转化一直具有挑战性，因为核酸容易被核酸酶降解，表现出不利的药代动力学，并且不能被动进入细胞。本综述强调了与 miRNA 模拟递送相关的挑战，然后讨论了聚合物纳米载体的设计和实施以克服这些挑战。总结了临床前的工作，并对聚合物纳米材料作为 miRNA 递送载体的未来临床转化提供了前瞻性的展望。 © 2019 Wiley periodicals, Inc. J. Appl。聚合物。科学。 2020 , 137 , 48651。

更新日期：2020-03-26

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11