Not so long ago, contact sites between the endoplasmic reticulum (ER) and lipid droplets (LDs) were largely unexplored on a molecular level. In recent years however, numerous proteins have been identified that are enriched or exclusively located at the interfaces between LDs and the ER. These comprise members of protein classes typically found in diverse types of contacts, such as organelle tethers and lipid transfer proteins, but also proteins that have no similarities to known contact site machineries. This structurally heterogeneous group of contact site residents might be required to fulfill unique aspects of LD-ER contact biology, such as de novo LD biogenesis, and maintenance of lipidic connections between LDs and ER. Here, we summarize the current knowledge on the molecular components of this special organelle contact site, and discuss their features and functions.

中文翻译：

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靠近一点！脂质液滴-ER接触部位越来越拥挤。

不久之前，内质网（ER）与脂质滴（LDs）之间的接触部位在分子水平上尚未得到充分探索。然而，近年来，已经鉴定出许多蛋白质，这些蛋白质被富集或仅位于LD与ER之间的界面处。它们包括通常在各种类型的接触中发现的蛋白质类别的成员，例如细胞器系链和脂质转移蛋白，以及与已知接触位点机械没有相似性的蛋白质。可能需要这种结构异质的接触部位居民群体来满足LD-ER接触生物学的独特方面，例如从头LD生物发生和维持LD与ER之间的脂质连接。在这里，我们总结了有关该特殊细胞器接触部位的分子成分的最新知识，