Condensates containing RNA polymerase II (Pol II) materialize at sites of active transcription. Young and coworkers now establish that C-terminal domain phosphorylation regulates Pol II partitioning into distinct condensates connected with transcription initiation or splicing. This advance hints that distinct condensates with specialized functional compositions might choreograph distinct stages of transcription.

中文翻译：

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切换冷凝物：CTD代码变为液体。

包含RNA聚合酶II（Pol II）的缩合物在活跃转录位点形成。现在，年轻的同事们确定C末端域的磷酸化作用可调节Pol II分配成与转录起始或剪接相关的不同缩合物。这一进展表明，具有特殊功能成分的不同缩合物可能会编排转录的不同阶段。