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CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials.
STEM CELLS ( IF 5.614 ) Pub Date : 2019-11-19 , DOI: 10.1002/stem.3112
Lijun Ding,Bianca Vezzani,Nusrat Khan,Jing Su,Lu Xu,Guijun Yan,Yong Liu,Ruotian Li,Anushri Gaur,Zhenyu Diao,Yali Hu,Zhongzhou Yang,W Reef Hardy,Aaron W James,Haixiang Sun,Bruno Péault

The tunica adventitia ensheathes arteries and veins and contains presumptive mesenchymal stem cells (MSCs) involved in vascular remodeling. We show here that a subset of human adventitial cells express the CD10/CALLA cell surface metalloprotease. Both CD10+ and CD10- adventitial cells displayed phenotypic features of MSCs when expanded in culture. However, CD10+ adventitial cells exhibited higher proliferation, clonogenic and osteogenic potentials in comparison to their CD10- counterparts. CD10+ adventitial cells increased expression of the cell cycle protein CCND2 via ERK1/2 signaling and osteoblastogenic gene expression via NF-κB signaling. CD10 expression was upregulated in adventitial cells through sonic hedgehog-mediated GLI1 signaling. These results suggest that CD10, which marks rapidly dividing cells in other normal and malignant cell lineages, plays a role in perivascular MSC function and cell fate specification. These findings also point to a role for CD10+ perivascular cells in vascular remodeling and calcification.
更新日期:2019-11-19

 

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