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Fabrication of novel MXene (Ti3C2)/polyacrylamide nanocomposite hydrogels with enhanced mechanical and drug release properties.
Soft Matter ( IF 2.9 ) Pub Date : 2019-11-13 , DOI: 10.1039/c9sm01985e Peng Zhang 1 , Xiu-Jie Yang 1 , Peng Li 1 , Yingyuan Zhao 2 , Qingshan Jason Niu 1
Soft Matter ( IF 2.9 ) Pub Date : 2019-11-13 , DOI: 10.1039/c9sm01985e Peng Zhang 1 , Xiu-Jie Yang 1 , Peng Li 1 , Yingyuan Zhao 2 , Qingshan Jason Niu 1
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A highly stretchable nanocomposite (NC) hydrogel was fabricated via in situ free radical polymerization of acrylamide. In particular, an exfoliated two-dimensional MXene (Ti3C2) nanosheet was utilized as a crosslinker instead of traditional organic crosslinkers. The exfoliated Ti3C2 nanosheets were confirmed by atomic force microscopy (AFM) and dynamic light scattering (DLS) measurements. Compared with traditional organic crosslinked N,N-methylene bisacrylamide (BIS)/polyacrylamide (PAM) hydrogels (fracture strength of 32.0 kPa and elongation of 109.6%), the synthesized Ti3C2/PAM NC hydrogels exhibited greatly improved mechanical properties with fracture strengths of 66.5 to 102.7 kPa, compressive strengths of 400.6 to 819.4 kPa and elongations at break of 2158.6% to 3047.5% as the Ti3C2 content increases from 0.0145% to 0.0436%. The enhanced mechanical performances can be attributed to the honeycomb-like fine structure with uniform pores as well as more flexible polymer chains in NC hydrogel networks. When loaded with drugs, Ti3C2/PAM NC hydrogels exhibited good sustained-release performance, higher drug loading amounts (97.5–127.7 mg g−1) and higher percentage releases (62.1–81.4%), greatly superior to those of the BIS/PAM hydrogel (46.4 mg g−1, 45.0%). Our work reveals the application of MXene materials in the fabrication of NC hydrogels with enhanced mechanical and drug release behaviors.
中文翻译：
具有增强的机械和药物释放性能的新型MXene（Ti3C2）/聚丙烯酰胺纳米复合水凝胶的制备。
通过丙烯酰胺的原位自由基聚合制备了高度可拉伸的纳米复合材料（NC）水凝胶。特别是，剥落的二维MXene（Ti 3 C 2）纳米片被用作交联剂，而不是传统的有机交联剂。剥落的Ti 3 C 2纳米片通过原子力显微镜（AFM）和动态光散射（DLS）测量得到确认。与传统的有机交联N，N-亚甲基双丙烯酰胺（BIS）/聚丙烯酰胺（PAM）水凝胶相比（断裂强度为32.0 kPa，伸长率为109.6％），合成的Ti 3 C 2/ PAM NC水凝胶的Ti 3 C 2含量从0.0145％增至0.0436％，其机械强度大大提高，断裂强度为66.5至102.7 kPa，抗压强度为400.6至819.4 kPa，断裂伸长率为2158.6％至3047.5 ％。增强的机械性能可归因于NC水凝胶网络中具有均匀孔隙的蜂窝状精细结构以及更柔韧的聚合物链。当负载药物时，Ti 3 C 2 / PAM NC水凝胶表现出良好的缓释性能，较高的载药量（97.5–127.7 mg g -1）和较高的释放百分比（62.1–81.4％），大大优于BIS / PAM水凝胶（46.4 mg g -1，45.0％）。我们的工作揭示了MXene材料在具有增强的机械和药物释放性能的NC水凝胶的制造中的应用。
更新日期：2019-11-13
中文翻译：
具有增强的机械和药物释放性能的新型MXene（Ti3C2）/聚丙烯酰胺纳米复合水凝胶的制备。
通过丙烯酰胺的原位自由基聚合制备了高度可拉伸的纳米复合材料（NC）水凝胶。特别是，剥落的二维MXene（Ti 3 C 2）纳米片被用作交联剂，而不是传统的有机交联剂。剥落的Ti 3 C 2纳米片通过原子力显微镜（AFM）和动态光散射（DLS）测量得到确认。与传统的有机交联N，N-亚甲基双丙烯酰胺（BIS）/聚丙烯酰胺（PAM）水凝胶相比（断裂强度为32.0 kPa，伸长率为109.6％），合成的Ti 3 C 2/ PAM NC水凝胶的Ti 3 C 2含量从0.0145％增至0.0436％，其机械强度大大提高，断裂强度为66.5至102.7 kPa，抗压强度为400.6至819.4 kPa，断裂伸长率为2158.6％至3047.5 ％。增强的机械性能可归因于NC水凝胶网络中具有均匀孔隙的蜂窝状精细结构以及更柔韧的聚合物链。当负载药物时，Ti 3 C 2 / PAM NC水凝胶表现出良好的缓释性能，较高的载药量（97.5–127.7 mg g -1）和较高的释放百分比（62.1–81.4％），大大优于BIS / PAM水凝胶（46.4 mg g -1，45.0％）。我们的工作揭示了MXene材料在具有增强的机械和药物释放性能的NC水凝胶的制造中的应用。
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