Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex.,Nature Neuroscience

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Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-11-11 , DOI: 10.1038/s41593-019-0523-z
Salman E Qasim ₁ , Jonathan Miller ₁ , Cory S Inman ₂ , Robert E Gross ₂ , Jon T Willie ₂ , Bradley Lega ₃ , Jui-Jui Lin ₃ , Ashwini Sharan ₄ , Chengyuan Wu ₄ , Michael R Sperling _{5,

6} , Sameer A Sheth ₇ , Guy M McKhann ₈ , Elliot H Smith ₉ , Catherine Schevon ₁₀ , Joel M Stein ₁₁ , Joshua Jacobs ₁

Affiliation

Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Department of Neurological Surgery, Emory University, Atlanta, GA, USA.
Department of Neurological Surgery, University of Texas Southwestern, Dallas, TX, USA.
Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Jefferson Comprehensive Epilepsy Center, Jefferson University Hospitals, Philadelphia, PA, USA.
Department of Neurological Surgery, Baylor College of Medicine, Houston, TX, USA.
Department of Neurological Surgery, Columbia University, New York, NY, USA.
Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
Department of Neurology, Columbia University, New York, NY, USA.
Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

The medial temporal lobe is critical for both spatial navigation and memory. Although single neurons in the medial temporal lobe activate to represent locations in the environment during navigation, how this spatial tuning relates to memory for events involving those locations remains unclear. We examined memory-related changes in spatial tuning by recording single-neuron activity from neurosurgical patients performing a virtual-reality object-location memory task. We identified 'memory-trace cells' with activity that was spatially tuned to the retrieved location of the specific object that participants were cued to remember. Memory-trace cells in the entorhinal cortex, in particular, encoded discriminable representations of different memories through a memory-specific rate code. These findings indicate that single neurons in the human entorhinal cortex change their spatial tuning to target relevant memories for retrieval.

中文翻译：

记忆检索调节人类内嗅皮层中单个神经元的空间调谐。

内侧颞叶对空间导航和记忆都至关重要。尽管内侧颞叶中的单个神经元在导航期间激活以表示环境中的位置，但这种空间调整如何与涉及这些位置的事件的记忆相关仍不清楚。我们通过记录执行虚拟现实对象位置记忆任务的神经外科患者的单神经元活动来检查空间调整中与记忆相关的变化。我们确定了“记忆追踪细胞”，其活动在空间上调整到参与者被提示记住的特定对象的检索位置。内嗅皮层中的记忆追踪细胞，特别是通过记忆特定的速率代码对不同记忆的可区分表示进行编码。

更新日期：2019-11-13

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