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Developmental Venous Anomaly Inside a Glioblastoma.
JAMA Neurology ( IF 20.4 ) Pub Date : 2020-01-01 , DOI: 10.1001/jamaneurol.2019.3840
Jose Danilo Bengzon Diestro 1 , Julian Spears 1, 2 , Thomas R Marotta 1, 2
Affiliation  

A 34-year-old man presented with a 3-week history of worsening headache and diplopia. A cranial computed tomography scan with findings consistent with a left frontal tumor prompted a referral to our institution. On admission, he was alert, oriented, and able to follow commands. The rest of his neurologic examination had unremarkable results, except for mild optic-disc swelling. The results of a metastatic workup with computed tomography were negative. Cranial magnetic resonance imaging showed a complex left frontal intraxial mass with heterogeneous enhancements. A prominent transmedullary vein consistent with the developmental venous anomaly (DVA) was also seen in the center of the mass (Figure 1A). A catheter angiogram confirmed the finding of a DVA, with the lesion appearing in the mid to late arterial phase (Figure 1B; Video). More importantly, the study demonstrated that the peritumoral brain parenchyma drained through the superior sagittal sinus rather than the DVA. Five days after admission, the patient underwent a left frontal craniotomy for resection of the tumor. A histopathologic examination revealed findings of a glioblastoma multiforme (Figure 2A and B). He was discharged within 2 days after surgery. Postoperative imaging demonstrated the adequate resection of both tumor and DVA.



中文翻译:

胶质母细胞瘤内的发育性静脉异常。

一名34岁的男子有3周的头痛和复视恶化史。颅骨计算机断层扫描扫描发现与左额叶肿瘤相符,提示转诊到我们的机构。入院时,他机敏,有针对性,并能够遵守命令。除轻度视盘肿胀外,其余的神经系统检查结果均无异常。计算机断层扫描的转移检查结果为阴性。颅脑磁共振成像显示复杂的左额叶内轴团,并具有异质性增强。在肿块中心还可见到与发育静脉异常(DVA)相一致的突出的经髓静脉(图1A)。导管血管造影证实发现了DVA,病变出现在动脉的中晚期(图1B;视频)。更重要的是,研究表明,瘤周围脑实质通过上矢状窦而不是DVA排出。入院五天后,患者进行了左侧额叶开颅手术,以切除肿瘤。组织病理学检查显示多形性胶质母细胞瘤的发现(图2A和B)。他在手术后两天内出院。术后影像学检查显示肿瘤和DVA均已切除。

更新日期:2020-01-13
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