Pancreatic steatosis is thought to be a negative risk factor for pancreas transplant outcomes. Despite considering donor body mass index (BMI) and the visualization of intercalated fat as indicators of donor pancreas lipid content, transplant surgeons do not use a quantitative method to directly measure steatosis when deciding to transplant a pancreas. In this study, we used nondiabetic human pancreata donated for research to measure the pancreatic and islet-specific lipid content to determine which clinical markers correlate best with lipid content. Interestingly, we found that BMI and age correlate with increased pancreatic lipid content (Panc-LC) in men, but not women. Our findings further suggest that total Panc-LC correlates with an increase in islet lipid content for both men and women. We noted that pancreata donated from individuals with a history of hypertension have increased Panc-LC independent of donor BMI or sex. Moreover, we identify hypertension as a risk factor for reduced islet function after islet isolation. Together, our findings emphasize differences in pancreas graft quality related to pancreatic and islet lipid content, which may not be predicted by assessing BMI alone but may be influenced by a donor history of hypertension.

中文翻译：

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高血压而非体重指数可预测胰腺脂质含量增加和胰岛功能障碍。

胰腺脂肪变性被认为是胰腺移植结果的负面危险因素。尽管考虑供体体重指数 (BMI) 和嵌入脂肪的可视化作为供体胰腺脂质含量的指标，移植外科医生在决定移植胰腺时并未使用定量方法直接测量脂肪变性。在这项研究中，我们使用捐赠用于研究的非糖尿病人胰腺来测量胰腺和胰岛特异性脂质含量，以确定哪些临床标志物与脂质含量最相关。有趣的是，我们发现 BMI 和年龄与男性胰腺脂质含量增加 (Panc-LC) 相关，但与女性无关。我们的研究结果进一步表明，总 Panc-LC 与男性和女性胰岛脂质含量的增加相关。我们注意到，从有高血压病史的个体捐赠的胰腺增加了与捐赠者 BMI 或性别无关的 Panc-LC。此外，我们将高血压确定为胰岛隔离后胰岛功能降低的危险因素。总之，我们的研究结果强调了与胰腺和胰岛脂质含量相关的胰腺移植物质量的差异，这可能无法通过单独评估 BMI 来预测，但可能会受到供体高血压病史的影响。