20(s)-ginsenoside Rg3 is a red ginseng-derived compound with the formula C42H72O13 that has been increasingly used by humans, leading to safety concerns regarding this use. In the current study, we conducted a 26-week study during which 20(S)-ginsenoside Rg3 (0, 7, 20, or 60 mg/kg) was continuously administered orally to Beagle dogs in order to explore its toxicity in these animals, with control dogs receiving a vehicle capsule. In total, 10 dogs received each dose of this compound (n = 5 male, n = 5 female per dose). Animals were continuously monitored for a 26-week administration period and a subsequent 4-week follow-up recovery period. At the end of study, we observed no evidence of 20(S)-ginsenoside Rg3 toxicity in clinical indications, body weight, food intake, ophthalmoscopy, electrocardiogram, urinalysis, hematology, serum biochemistry, gross and histopathology findings. However, the kidney relative weight of animals receiving 60 mg/kg of compound was significantly elevated relative to control animals (5.15 ± 0.88‰ vs. 4.11 ± 0.59‰. P < 0.05), and this effect was reversed after 4-week recovery period. Based on these results, the NOAEL value for orally administered 20(S)-ginsenoside Rg3 in dogs is 20 mg/kg.

中文翻译：

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在比格犬中进行的为期26周的20（S）-人参皂甙Rg3口服毒性研究。

20（s）-人参皂苷Rg3是人参来源的具有化学式C42H72O13的红参来源化合物，已被越来越多的人使用，导致对该用途的安全性担忧。在当前的研究中，我们进行了为期26周的研究，在此研究中，连续向Beagle犬口服20（S）-人参皂甙Rg3（0、7、20或60 mg / kg），以研究其对这些动物的毒性，其中的控制犬会收到载剂胶囊。总共有10只狗接受每种剂量的该化合物（每剂量n = 5雄性，n = 5雌性）。连续监测动物26周的给药期和随后的4周的随访恢复期。在研究结束时，我们没有观察到20（S）-人参皂甙Rg3在临床适应症，体重，食物摄入，检眼镜，心电图，尿液分析，血液学，血清生化，肉眼和组织病理学发现。然而，相对于对照动物，接受60 mg / kg化合物的动物的肾脏相对体重显着升高（5.15±0.88‰vs. 4.11±0.59‰。P<0.05），并且在恢复4周后这种作用被逆转。根据这些结果，在犬中口服施用20（S）-人参皂苷Rg3的NOAEL值为20 mg / kg。