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Companion Diagnostics to Identify Biomarkers of Response to Anticancer Drugs Targeting the Proteome.
Cancer Cell ( IF 48.8 ) Pub Date : 2019-11-11 , DOI: 10.1016/j.ccell.2019.10.003
Anthony M Joshua 1 , Ian F Tannock 2
Affiliation  

In this issue of Cancer Cell, Pillarsetty and colleagues radiolabel the potential anticancer drug PU-H71 and use it with PET imaging to quantify the epichaperome protein complex in tumors and its inhibition by the drug. They thereby develop a companion diagnostic paradigm of probe-drug pairing to explore therapeutic potential.

中文翻译:

伴侣诊断可识别针对蛋白质组的抗癌药物反应的生物标志物。

在这一期的《癌细胞》中,Pillarsetty及其同事对潜在的抗癌药物PU-H71进行了放射性标记,并将其与PET成像结合使用以量化肿瘤中的表壳蛋白复合物及其对药物的抑制作用。因此,他们开发了探针-药物配对的伴随诊断范例,以探索治疗潜力。
更新日期:2019-11-13
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