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Stressing Out about Cancer Immunotherapy.
Cancer Cell ( IF 48.8 ) Pub Date : 2019-11-11 , DOI: 10.1016/j.ccell.2019.10.013
Xue-Yan He 1 , David Ng 1 , Linda Van Aelst 1 , Mikala Egeblad 1
Affiliation  

Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells-the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3-as a potent, immunosuppressive effect of stress on cancer.

中文翻译:

强调癌症免疫疗法。

长期以来,人们一直怀疑压力会对癌症的死亡率产生负面影响,但仅在最近才发现了引起这种作用的分子机制。一项新的研究确定了树突状细胞中应激诱导的反应-糖皮质激素诱导的转录调节剂TSC22D3-的激活是应激对癌症的有效免疫抑制作用。
更新日期:2019-11-13
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