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Building de novo cryo-electron microscopy structures collaboratively with citizen scientists.
PLOS Biology ( IF 7.8 ) Pub Date : 2019-11-12 , DOI: 10.1371/journal.pbio.3000472
Firas Khatib 1 , Ambroise Desfosses 2 , , Brian Koepnick 3 , Jeff Flatten 4 , Zoran Popović 4 , David Baker 3 , Seth Cooper 5 , Irina Gutsche 2 , Scott Horowitz 6
Affiliation  

With the rapid improvement of cryo-electron microscopy (cryo-EM) resolution, new computational tools are needed to assist and improve upon atomic model building and refinement options. This communication demonstrates that microscopists can now collaborate with the players of the computer game Foldit to generate high-quality de novo structural models. This development could greatly speed the generation of excellent cryo-EM structures when used in addition to current methods.

中文翻译:

与公民科学家合作构建从头的低温电子显微镜结构。

随着低温电子显微镜(cryo-EM)分辨率的快速提高,需要新的计算工具来辅助和改进原子模型的建立和改进选择。这种交流表明,显微学家现在可以与计算机游戏Foldit的玩家合作,以生成高质量的从头结构模型。除当前方法外,这种发展还可以大大加快优秀的冷冻-EM结构的产生。
更新日期:2019-12-03
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