Understanding the development of apicobasal polarity (ABP) is a long-standing problem in biology. The molecular components involved in the development and maintenance of APB have been largely identified and are known to have ubiquitous roles across organisms. Our knowledge of the functional consequences of ABP establishment and maintenance is far less comprehensive. Recent studies using novel experimental approaches and cellular models have revealed a growing link between ABP and the genetic program of cell lineage. This mini-review describes some of the most recent advances in this new field, highlighting examples from Caenorhabditis elegans and mouse embryos, human pluripotent stem cells, and epithelial cells. We also speculate on the most interesting and challenging avenues that can be explored.

中文翻译：

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将apapobasal极性链接到细胞命运规范的新方法。

了解顶突极性（ABP）的发展是生物学中一个长期存在的问题。很大程度上已经确定了涉及APB的开发和维持的分子成分，并且已知它们在整个生物体中都具有普遍的作用。我们对ABP建立和维护的功能后果的了解还不够全面。最近使用新颖的实验方法和细胞模型进行的研究表明，ABP与细胞谱系遗传程序之间的联系日益紧密。这份小型综述介绍了该新领域中的一些最新进展，重点介绍了秀丽隐杆线虫和小鼠胚胎，人多能干细胞和上皮细胞的例子。我们还推测了可以探索的最有趣和最具挑战性的途径。