Following the systematic nomenclature recommended by the IUPAC for other π,σ-hole interactions, a nobel gas (or aerogen) bond (NgB) is defined as the attractive interaction between an electron rich atom or group of atoms and any element of Group-18 acting as electron acceptor. Investigations on π,σ-hole interactions and their applications in crystal engineering, molecular recognition and catalysis have exponentially grown in recent years. For obvious reasons, investigations on noncovalent Ng bonding interactions are less abundant compared to their sisters (halogen, chalcogen, pnictogen and tetrel bonding, namely XB, ChB, PnB and TrB, respectively). In this review, we put into perspective the available theoretical and experimental investigations on σ-hole and π-hole interactions involving noble gas atoms. We describe a number of theoretical works revealing that NgB follows the typical behavior already described for XB, ChB, PnB and TrB, where stronger interactions occur moving the whole group down. A search the Cambridge Structural Database (CSD) and Inorganic Crystal Structure Database (ICSD) reveals that there are several X-ray structures of xenon derivatives where NgB interaction is crucial for the crystal packing stability. This taking is sub-divided into three sections subject to the oxidation state of xenon. The crystallographic search evidences that interactions between Xe and electron rich atoms are frequent and directional.

遵循IUPAC建议的其他π，σ-空穴相互作用的系统命名法，将诺贝尔气体（或气源）键（NgB）定义为富电子原子或原子团与18号族任何元素之间的吸引相互作用充当电子受体。近年来，关于π，σ-空穴相互作用及其在晶体工程，分子识别和催化中的应用的研究呈指数增长。出于明显的原因，与它们的姊妹（卤素，硫属元素，光子原和蝶形键，分别为XB，ChB，PnB和TrB）相比，对非共价Ng键相互作用的研究较少。在这篇综述中，我们将涉及稀有气体原子的σ-孔和π-孔相互作用的可用理论和实验研究纳入了视角。我们描述了许多理论工作，这些工作揭示了NgB遵循已经针对XB，ChB，PnB和TrB描述的典型行为，其中发生了更强的相互作用，使整个群体向下移动。在剑桥结构数据库（CSD）和无机晶体结构数据库（ICSD）中进行的搜索显示，氙气衍生物存在多种X射线结构，其中NgB相互作用对于晶体堆积稳定性至关重要。根据氙的氧化态，将这种摄取分为三个部分。晶体学研究证明，Xe与富电子原子之间的相互作用是频繁且有方向性的。对剑桥结构数据库（CSD）和无机晶体结构数据库（ICSD）进行的搜索显示，氙气衍生物存在多种X射线结构，其中NgB相互作用对于晶体堆积稳定性至关重要。根据氙的氧化态，将这种摄取分为三个部分。晶体学研究证明，Xe与富电子原子之间的相互作用是频繁且有方向性的。对剑桥结构数据库（CSD）和无机晶体结构数据库（ICSD）进行的搜索显示，氙气衍生物存在多种X射线结构，其中NgB相互作用对于晶体堆积稳定性至关重要。根据氙的氧化态，将这种摄取分为三个部分。晶体学研究证明，Xe与富电子原子之间的相互作用是频繁且有方向性的。