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Bioactive terpenoid constituents from Eclipta prostrata
Phytochemistry ( IF 3.2 ) Pub Date : 2020-02-01 , DOI: 10.1016/j.phytochem.2019.112192 Shu-Juan Yu 1 , Jin-Hai Yu 2 , Zhi-Pu Yu 1 , Xue Yan 1 , Jun-Sheng Zhang 2 , Jin-Yue Sun 3 , Hua Zhang 2
Phytochemistry ( IF 3.2 ) Pub Date : 2020-02-01 , DOI: 10.1016/j.phytochem.2019.112192 Shu-Juan Yu 1 , Jin-Hai Yu 2 , Zhi-Pu Yu 1 , Xue Yan 1 , Jun-Sheng Zhang 2 , Jin-Yue Sun 3 , Hua Zhang 2
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Chemical fractionation of the ethanolic extract of Eclipta prostrata yielded a series of unreported terpenoid constituents, including a rare 6/6/6/6-fused tetracyclic triterpenoid, a pentacyclic triterpenoid, two pentacyclic triterpenoid saponins, a diterpenoid and a sesquiterpenoid. Structures were assigned to these compounds on the basis of comprehensive spectroscopic analyses, with the absolute configurations of the tetracyclic triterpenoid, the diterpenoid and the sesquiterpenoid being determined via explanation of electronic circular dichroism data. Screening of these isolates in an array of bioassays revealed antibacterial, cytotoxic and α-glucosidase inhibitory activities for selective compounds. Of particular interest, the tetracyclic triterpenoid showed very strong inhibition against α-glucosidase with an IC50 of 0.82 ± 0.18 μM, being 103-fold as active as the positive control acarbose.
中文翻译：
旱莲草的生物活性萜类成分
旱旱莲乙醇提取物的化学分馏产生了一系列未报告的萜类成分，包括稀有的 6/6/6/6 稠合四环三萜、五环三萜、两种五环三萜皂苷、二萜和倍半萜。在综合光谱分析的基础上为这些化合物分配了结构，四环三萜、二萜和倍半萜的绝对构型通过电子圆二色性数据的解释确定。在一系列生物测定中筛选这些分离物揭示了选择性化合物的抗菌、细胞毒性和 α-葡萄糖苷酶抑制活性。特别令人感兴趣的是，四环三萜对 α-葡萄糖苷酶显示出非常强的抑制作用，IC50 为 0.82 ± 0.18 μM，
更新日期：2020-02-01
中文翻译：
旱莲草的生物活性萜类成分
旱旱莲乙醇提取物的化学分馏产生了一系列未报告的萜类成分，包括稀有的 6/6/6/6 稠合四环三萜、五环三萜、两种五环三萜皂苷、二萜和倍半萜。在综合光谱分析的基础上为这些化合物分配了结构，四环三萜、二萜和倍半萜的绝对构型通过电子圆二色性数据的解释确定。在一系列生物测定中筛选这些分离物揭示了选择性化合物的抗菌、细胞毒性和 α-葡萄糖苷酶抑制活性。特别令人感兴趣的是，四环三萜对 α-葡萄糖苷酶显示出非常强的抑制作用，IC50 为 0.82 ± 0.18 μM，
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