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Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection.
International Journal for Parasitology ( IF 3.7 ) Pub Date : 2019-11-11 , DOI: 10.1016/j.ijpara.2019.08.002 Bikash Ranjan Giri 1 , Guofeng Cheng 1
International Journal for Parasitology ( IF 3.7 ) Pub Date : 2019-11-11 , DOI: 10.1016/j.ijpara.2019.08.002 Bikash Ranjan Giri 1 , Guofeng Cheng 1
Affiliation
Extracellular vesicles are critical regulators of host-parasite interactions. We previously demonstrated that Schistosoma japonicum EVs contain a remarkably high abundance of host miR-148a. Here, we characterised the abundance of miR-148a in circulation, in peripheral immune cells, and in plasma EVs of S. japonicum-infected mice. The results suggested the high abundance of miR-148a in macrophages to be likely linked to S. japonicum EVs. Additionally, miR-148a was found to target PTEN through the PI3K/AKT pathway to regulate cytokine production in macrophages. Consequently, our findings suggest that high abundance of miR-148a in macrophages may be associated with S. japonicum EVs, and regulate the host immune response during schistosome infection.
中文翻译:
日本血吸虫感染期间,宿主miR-148调节巨噬细胞介导的免疫反应。
细胞外囊泡是宿主-寄生虫相互作用的关键调节剂。我们以前证明日本血吸虫EV含有大量的宿主miR-148a。在这里,我们表征了日本血吸虫感染小鼠的循环,外周免疫细胞和血浆电动汽车中miR-148a的丰度。结果表明巨噬细胞中miR-148a的高丰度可能与日本血吸虫电动车有关。另外,发现miR-148a通过PI3K / AKT途径靶向PTEN,以调节巨噬细胞中细胞因子的产生。因此,我们的发现表明巨噬细胞中miR-148a的高丰度可能与日本血吸虫EV有关,并在血吸虫感染期间调节宿主的免疫反应。
更新日期:2019-11-11
中文翻译:
日本血吸虫感染期间,宿主miR-148调节巨噬细胞介导的免疫反应。
细胞外囊泡是宿主-寄生虫相互作用的关键调节剂。我们以前证明日本血吸虫EV含有大量的宿主miR-148a。在这里,我们表征了日本血吸虫感染小鼠的循环,外周免疫细胞和血浆电动汽车中miR-148a的丰度。结果表明巨噬细胞中miR-148a的高丰度可能与日本血吸虫电动车有关。另外,发现miR-148a通过PI3K / AKT途径靶向PTEN,以调节巨噬细胞中细胞因子的产生。因此,我们的发现表明巨噬细胞中miR-148a的高丰度可能与日本血吸虫EV有关,并在血吸虫感染期间调节宿主的免疫反应。