Marsupials and eutherians are mammals that differ in their physiological traits, predominately their reproductive and developmental strategies; eutherians give birth to well-developed young, while marsupials are born highly altricial after a much shorter gestation. These developmental traits also result in differences in the development of the immune system of eutherian and marsupial species. In eutherians, B-cells are the key to humoral immunity as they are found in multiple lymphoid organs and have the unique ability to mediate the production of antigen-specific antibodies in the presence of extracellular pathogens. The development of B-cells in marsupials has been reported and hypothesised to be similar to that of eutherians, except that haematopoiesis occurs in the liver, postpartum, until the bone marrow fully matures. In eutherians, specific genes are linked to specific stages in B-cell development, maturation, and differentiation processes, and have been identified including immunoglobulins (heavy and light chains), cluster of differentiation markers (CD10, 19, 34 and CD79α/β), signal transduction molecules (BTK, Lyn and Syk) and transcriptional regulators (EBF1, E2A, and Pax5). This review aims to discuss the known similarities and differences between marsupial and eutherian B-cells, in regards to their genetic presence, homology, and developmental stages, as well as to highlight the areas requiring further investigation. By enhancing our understanding of the genes that are involved with B-cells in the marsupial lineage, it will, in turn, aid our understanding of the marsupial immune system and support the development of specific immunological reagents for research and wildlife conservation purposes.

中文翻译：

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有袋B细胞的免疫遗传学。

有袋动物和以太动物是具有不同生理特征的哺乳动物，主要是它们的生殖和发育策略。有品位的人会生出一个发育良好的年轻人，而有袋动物的出生时间要短得多。这些发育特征还导致了有色植物和有袋动物的免疫系统发育的差异。在乙肝患者中，B细胞是体液免疫的关键，因为它们存在于多个淋巴器官中，并具有在细胞外病原体存在下介导抗原特异性抗体产生的独特能力。据报道，有袋动物中B细胞的发育和假设与真人相似，只是造血作用发生在产后的肝脏，直到骨髓完全成熟。在以太坊里，特定基因与B细胞发育，成熟和分化过程中的特定阶段相关，并且已被鉴定出包括免疫球蛋白（重链和轻链），分化标志物簇（CD10、19、34和CD79α/β），信号转导分子（BTK，Lyn和Syk）和转录调节因子（EBF1，E2A和Pax5）。这篇综述的目的是讨论有袋和乙型B细胞在遗传存在，同源性和发育阶段方面的已知异同，并着重指出需要进一步研究的领域。通过加深我们对有袋动物世系B细胞所涉及基因的理解，它将反过来，