Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration.,Advanced Healthcare Materials

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Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-11-12 , DOI: 10.1002/adhm.201901321
Scott T Keene ₁ , Daragh Fogarty ₁ , Ross Cooke ₁ , Carlos D Casadevall ₁ , Alberto Salleo ₁ , Onur Parlak ₁

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Wearable health monitoring has garnered considerable interest from the healthcare industry as an evolutionary alternative to standard practices with the ability to provide rapid, off-site diagnosis and patient-monitoring. In particular, sweat-based wearable biosensors offer a noninvasive route to continuously monitor a variety of biomarkers for a range of physiological conditions. Both the accessibility and wealth of information of sweat make it an ideal target for noninvasive devices that can aid in early diagnosis of disease or to monitor athletic performance. Here, the integration of ammonium (NH4 + ) and calcium (Ca2+ ) ion-selective membranes with a poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)-based (PEDOT:PSS) organic electrochemical transistor (OECT) for multiplexed sensing of NH4 + and Ca2+ in sweat with high sensitivity and selectivity is reported for the first time. The presented wearable sweat sensor is designed by combining a flexible and stretchable styrene-ethylene-butene-styrene substrate with a laser-patterned microcapillary channel array for direct sweat acquisition and delivery to the ion-selective OECT. The resulting dermal sensor exhibits a wide working range between 0.01 × 10-3 and 100 × 10-3 m, well within the physiological levels of NH4 + and Ca2+ in sweat. The integrated devices are successfully implemented with both ex situ measurements and on human subjects with real-time analysis using a wearable sensor assembly.

中文翻译：

穿戴式有机电化学晶体管贴片，用于人类汗液中钙和铵离子的多重传感。

可穿戴式健康监控已成为可替代标准操作方法的替代方法，可提供快速的异地诊断和患者监护能力，已引起医疗保健行业的广泛关注。特别是，基于汗液的可穿戴生物传感器提供了一种无创途径，可以针对一系列生理条件连续监测各种生物标志物。汗液的可访问性和丰富的信息使其成为非侵入性设备的理想目标，这些设备可以帮助疾病的早期诊断或监测运动表现。在这里，铵（NH4 +）和钙（Ca2 +）离子选择膜与基于聚（3,4-乙撑二氧噻吩）：聚（苯乙烯磺酸盐）的（PEDOT：首次报道了以高灵敏度和高选择性对汗液中的NH4 +和Ca2 +进行多重感测的PSS有机电化学晶体管（OECT）。提出的可穿戴汗液传感器是通过将柔性，可拉伸的苯乙烯-乙烯-丁烯-苯乙烯基体与激光图案化的微毛细管通道阵列相结合而设计的，以直接吸收汗液并将其输送至离子选择性OECT。所得的真皮传感器在0.01×10-3至100×10-3 m的宽工作范围内，处于汗液中NH4 +和Ca2 +的生理水平之内。集成设备可以通过易地测量和使用可穿戴传感器组件进行实时分析的人体对象成功实现。提出的可穿戴汗液传感器是通过将柔性，可拉伸的苯乙烯-乙烯-丁烯-苯乙烯基体与激光图案化的微毛细管通道阵列相结合而设计的，以直接吸收汗液并将其输送至离子选择性OECT。所得的真皮传感器在0.01×10-3至100×10-3 m的宽工作范围内，处于汗液中NH4 +和Ca2 +的生理水平之内。集成设备可以通过易地测量和使用可穿戴传感器组件进行实时分析的人体对象成功实现。提出的可穿戴汗液传感器是通过将柔性，可拉伸的苯乙烯-乙烯-丁烯-苯乙烯基体与激光图案化的微毛细管通道阵列相结合而设计的，以直接吸收汗液并将其输送至离子选择性OECT。所得的真皮传感器在0.01×10-3至100×10-3 m的宽工作范围内，处于汗液中NH4 +和Ca2 +的生理水平之内。集成设备可以通过易地测量和使用可穿戴传感器组件进行实时分析的人体对象成功实现。在汗液中的NH4 +和Ca2 +的生理水平之内。集成设备可以通过易地测量和使用可穿戴传感器组件进行实时分析的人体对象成功实现。汗液中的NH4 +和Ca2 +的生理水平都很好。集成设备可以通过易地测量和使用可穿戴传感器组件进行实时分析的人体对象成功实现。

更新日期：2019-12-19

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