Glycans – simple or complex carbohydrates – play key roles as recognition determinants and modulators of numerous physiological and pathological processes. Thus, many biotechnological, diagnostic and therapeutic opportunities abound for molecular recognition entities that can bind glycans with high selectivity and affinity. This review begins with an overview of the current biologically and synthetically derived glycan-binding scaffolds that include antibodies, lectins, aptamers and boronic acid-based entities. It is followed by a more detailed discussion on various aspects of their generation, structure and recognition properties. It serves as the basis for highlighting recent key developments and technical challenges that must be overcome in order to fully deal with the specific recognition of a highly diverse and complex range of glycan structures.

中文翻译：

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天然和人工受体识别聚糖的挑战。

糖类（简单或复杂的碳水化合物）在众多生理和病理过程的识别决定因素和调节剂中起着关键作用。因此，对于可以以高选择性和亲和力结合聚糖的分子识别实体而言，存在许多生物技术，诊断和治疗机会。这篇综述首先概述了目前生物和合成衍生的聚糖结合支架，包括抗体，凝集素，适体和基于硼酸的实体。接下来是关于它们的生成，结构和识别属性的各个方面的更详细的讨论。