The Medtronic MiniMed 670G system delivers insulin to patients with type 1 diabetes mellitus (T1DM) using either its hybrid closed-loop (HCL) "Auto Mode" feature or an open-loop mode. In this retrospective, cross-sectional analysis, we quantified the association between time in Auto Mode and both haemoglobin A1c (HbA1c) and time in range (TIR, sensor glucose 70-180 mg/dL) among 96 paediatric and young adult patients with T1DM. The median percentage time in Auto Mode was 38.5% (interquartile range 0%-64%). The percentage time in Auto Mode significantly correlated with HbA1c after adjustment for covariables (β = -0.008, P = 0.014). Each daily 3.4-h increase in Auto Mode time was associated with a 0.1% decrease in HbA1c. Auto Mode time was also correlated with TIR after adjustment for covariables (β = 0.14, P = 0.02): for each daily 8.6-h increase in Auto Mode time, TIR increased by 5%. While Auto Mode use was low, increased time in Auto Mode was associated with a significantly lower HbA1c and increased TIR. These findings emphasize the importance of identifying strategies to improve the ease of use of HCL systems.

中文翻译：

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使用MiniMed 670G胰岛素泵，在混合闭环“自动模式”中增加的时间比例与改善成人1型糖尿病青少年的血糖控制有关。

Medtronic MiniMed 670G系统使用其混合闭环（HCL）“自动模式”功能或开环模式向1型糖尿病（T1DM）患者输送胰岛素。在此回顾性横断面分析中，我们量化了96例小儿和年轻成人T1DM患者在自动模式下的时间与血红蛋白A1c（HbA1c）和范围内时间（TIR，传感器葡萄糖70-180 mg / dL）之间的关联。自动模式下的中位百分比时间为38.5％（四分位间距为0％-64％）。调整协变量后，自动模式下的百分比时间与HbA1c显着相关（β= -0.008，P = 0.014）。自动模式时间每天增加3.4小时，HbA1c减少0.1％。调整协变量后，自动模式时间也与TIR相关（β= 0.14，P = 0.02）：每天8次。自动模式时间增加6小时，TIR增加5％。尽管“自动模式”使用率较低，但“自动模式”中时间的增加与HbA1c的显着降低和TIR的增加有关。这些发现强调了确定提高HCL系统易用性的策略的重要性。