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Evaluation of the pesticide Oberon on a model organism Drosophila melanogaster via topical toxicity test on biochemical and reproductive parameters.
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2019-11-11 , DOI: 10.1016/j.cbpc.2019.108666 N Kissoum 1 , H Bensafi-Gheraibia 1 , Z C Hamida 1 , N Soltani 1
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2019-11-11 , DOI: 10.1016/j.cbpc.2019.108666 N Kissoum 1 , H Bensafi-Gheraibia 1 , Z C Hamida 1 , N Soltani 1
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Spiromesifen (Oberon® 240 SC), a pesticide widely used to control pests like mites and whiteflies, was investigated using Drosophila melanogaster Meigen, 1830 (Diptera, Drosophilidae) as a model organism. The compound was applied topically at two concentrations (LC10: 21.45 and LC25: 39.53 μg active ingredient/pupa), on newly molted pupae and assessed on morphometric measurements of ovaries and the progeny of surviving adults. Results showed that spiromesifen inhibited the growth and development of ovaries, reducing at the highest dose (LC25) the number of oocytes, the volume of basal oocytes and ovarian weight. Biochemical analysis revealed that the tested compound reduced the ovarian levels of carbohydrates and glycogen during the sexual maturation. Moreover, fecundity, fertility and number of descendants from parents that survived to the treatment of pupae were significantly reduced. The sex ratio determined indicated a significant decrease in treated series and males seemed more sensitive to spiromesifen than females. Lastly, the compound was found to affect the sexual behavior.
中文翻译：
通过对生化参数和生殖参数的局部毒性测试，评估农药Oberon对模型生物果蝇（Drosophila melanogaster）的评价。
Spiromesifen（Oberon®240 SC）是一种广泛用于控制害虫（如螨虫和粉虱）的农药，使用果蝇（Drosophila melanogaster Meigen，1830）（Diptera，Drosophilidae）作为模型生物进行了研究。将该化合物以两种浓度（LC10：21.45和LC25：39.53μg活性成分/ pu）局部应用在新蜕化的p上，并通过卵巢和成年后代的形态计量学评估。结果显示，螺西莫芬抑制卵巢的生长和发育，在最高剂量（LC25）下可减少卵母细胞的数量，基础卵母细胞的体积和卵巢重量。生化分析表明，该化合物在性成熟过程中降低了卵巢中碳水化合物和糖原的水平。而且，生育力 of的存活率和幸存下来的父母的后代的数量显着降低。所确定的性别比表明治疗的系列药物显着减少，男性似乎比女性对spiromesifen更为敏感。最后，发现该化合物影响性行为。
更新日期：2019-11-11
中文翻译：
通过对生化参数和生殖参数的局部毒性测试，评估农药Oberon对模型生物果蝇（Drosophila melanogaster）的评价。
Spiromesifen（Oberon®240 SC）是一种广泛用于控制害虫（如螨虫和粉虱）的农药，使用果蝇（Drosophila melanogaster Meigen，1830）（Diptera，Drosophilidae）作为模型生物进行了研究。将该化合物以两种浓度（LC10：21.45和LC25：39.53μg活性成分/ pu）局部应用在新蜕化的p上，并通过卵巢和成年后代的形态计量学评估。结果显示，螺西莫芬抑制卵巢的生长和发育，在最高剂量（LC25）下可减少卵母细胞的数量，基础卵母细胞的体积和卵巢重量。生化分析表明，该化合物在性成熟过程中降低了卵巢中碳水化合物和糖原的水平。而且，生育力 of的存活率和幸存下来的父母的后代的数量显着降低。所确定的性别比表明治疗的系列药物显着减少，男性似乎比女性对spiromesifen更为敏感。最后，发现该化合物影响性行为。
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