Novel approaches to vaccine development include structure-based immunogen design, gene-based vaccine platforms and formulation of recombinant antigens with potent adjuvants. These technologies are producing encouraging results in the development of vaccines for globally important diseases such as tuberculosis, influenza and respiratory syncytial virus. Here we highlight the most important developments in these areas over the past 18 months. New approaches to vaccine development have generated exciting results over the past 18 months. Focusing on respiratory syncytial virus infection, influenza and tuberculosis, Fauci and Mascola discuss the impact of structure-based vaccine design, gene-based vaccine platforms and advances in adjuvant development.

中文翻译：

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21 世纪的新型疫苗技术。


疫苗开发的新方法包括基于结构的免疫原设计、基于基因的疫苗平台以及使用有效佐剂配制重组抗原。这些技术在结核病、流感和呼吸道合胞病毒等全球重要疾病的疫苗开发方面取得了令人鼓舞的成果。在此，我们重点介绍过去 18 个月这些领域最重要的进展。过去 18 个月里，疫苗开发的新方法取得了令人兴奋的成果。福奇和马斯科拉重点关注呼吸道合胞病毒感染、流感和结核病，讨论了基于结构的疫苗设计、基于基因的疫苗平台和佐剂开发进展的影响。