Gradient Polymerization-Induced Self-Assembly: A One-Step Approach.,Macromolecular Rapid Communications

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Gradient Polymerization-Induced Self-Assembly: A One-Step Approach.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2019-11-10 , DOI: 10.1002/marc.201900493
Sihao Xu ₁ , Tong Zhang ₁ , Rhiannon P Kuchel ₂ , Jonathan Yeow ₁ , Cyrille Boyer ₁

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In this work, the authors report a novel single-step, one-pot process for the synthesis of self-assembled nanoparticles using a polymerization-induced self-assembly (PISA) mechanism. In contrast to conventional approaches employing a pre-formed macromolecular stabilizer, the disparate reactivities between two monomers, oligo(ethylene glycol) methyl ether methacrylate (OEGMA) and diacetone acrylamide (DAAm), are exploited instead to synthesize a gradient copolymer directly in aqueous solution. Due to the hydrophobicity of poly(DAAm), these gradient copolymers can self-assemble in situ to form spheres and worms stabilized by the OEGMA residues. A surprisingly broad range of parameters are identified in which the worm morphology can be stabilized, which is highlighted by significant gelation of the reaction mixture in situ. This single-step gradient copolymerization approach to PISA is more efficient than conventional two-step syntheses. These results demonstrate improved reproducibility owing to the production of self-assembled nanoparticles directly in a one-pot and single-step synthesis.

中文翻译：

梯度聚合诱导的自组装：一步法。

在这项工作中，作者报告了一种使用聚合诱导的自组装（PISA）机制合成自组装纳米粒子的新颖的单步一锅法。与采用预先形成的大分子稳定剂的常规方法相比，利用两种单体（低聚乙二醇甲基丙烯酸甲酯（OEGMA）和双丙酮丙烯酰胺（DAAm））之间的完全反应性来直接在水溶液中合成梯度共聚物。由于聚（DAAm）的疏水性，这些梯度共聚物可以原位自组装形成球形和由OEGMA残留物稳定的蠕虫。可以识别出令人惊讶的范围广泛的参数，可以稳定蠕虫的形态，这通过反应混合物在原位的显着凝胶化得以突出。这种用于PISA的单步梯度共聚方法比常规的两步合成方法更有效。这些结果表明，由于直接在一个罐中一步一步合成自组装纳米颗粒，从而提高了可重复性。

更新日期：2019-11-11

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