Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric tumor with no currently available treatment options. More than 60–70% DIPG tumors harbor heterozygous mutations at genes encoding histone H3 proteins that replace lysine 27 with methionine (K27M). In this review, we discuss how K27M mutation reprograms the cancer epigenome to lead to tumorigenesis, and highlight potential drug targets and therapeutic agents for DIPG.

中文翻译：

---

弥漫性内源性庞廷胶质瘤中的癌石突变。

弥漫性桥脑神经胶质瘤（DIPG）是一种致命的小儿肿瘤，目前尚无可用的治疗方法。超过60–70％的DIPG肿瘤在编码组蛋白H3蛋白的基因上带有杂合突变，这些蛋白用蛋氨酸（K27M）取代了赖氨酸27。在这篇综述中，我们讨论K27M突变如何重编程癌症表观基因组以导致肿瘤发生，并重点介绍DIPG的潜在药物靶标和治疗剂。