Studying Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, requires different model systems, including patient-specific induced pluripotent stem cell lines. With the help of non-integrating episomal vectors the iPSC lines ICGi015-A and ICGi015-B were generated from blood mononuclear cells of PD patient, carrying three SNPs, associated with PD development. The obtained iPSC lines express pluripotency markers and demonstrate the ability to in vitro differentiate into the three germ layers. These cell lines may be useful for studying molecular mechanisms of PD and for drug screening.

中文翻译：

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通过对患有帕金森氏病的患者的外周血单核细胞进行重新编程，可以生成两条iPSC系（ICGi015-A和ICGi015-B）。

研究帕金森氏病（PD）是世界上最常见的神经退行性疾病之一，它需要不同的模型系统，包括患者特异性诱导的多能干细胞系。借助于非整合型附加型载体，iPDC系ICGi015-A和ICGi015-B从带有3个SNP的PD患者的PD患者血液单核细胞中产生。所获得的iPSC品系表达多能性标记，并证明了体外分化为三个胚层的能力。这些细胞系可用于研究PD的分子机制和药物筛选。