We previously reported that some, but not all, multidrug-resistant cells that overexpressed various drug-resistance transporters were collaterally sensitive to tiopronin. In recent follow-up studies, we discovered that sensitivity to tiopronin in the original study was mediated by infection of the cells by a human-specific strain of mycoplasma. These results strongly support the need to constantly monitor cells for mycoplasma infection and keep stored samples of all cells that are used for in vitro studies.

中文翻译：

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支原体感染介导多药耐药细胞系对硫普罗宁的敏感性：一个警告性的故事。

我们先前曾报道过，但并非全部，过分表达多种药物抗性转运蛋白的多药耐药性细胞对噻普罗宁有侧向敏感性。在最近的后续研究中，我们发现原始研究中对噻普罗宁的敏感性是由人类特异性支原体菌株感染细胞所介导的。这些结果强烈支持需要不断监测细胞支原体感染并保存所有用于体外研究的细胞样品的需求。