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New trihydroxybriarane diterpenoids from an octocoral Briareum sp
Phytochemistry Letters ( IF 1.3 ) Pub Date : 2019-11-10 , DOI: 10.1016/j.phytol.2019.10.003
Chiung-Chin Hu , Nai-Cheng Lin , Bo-Rong Peng , You-Ying Chen , Zhi-Hong Wen , Yu-Chia Chang , Gene-Hsiang Lee , Yang-Chang Wu , Ping-Jyun Sung

Chemical investigation of the extract from the supercritical CO2 extraction of an octocoral identified as Briareum sp., afforded a known briarane-type diterpenoid, excavatolide B (1), and a pair of new briaranes, briaviolides Y (2) and Z (3). The absolute configuration of 1 was determined by a single-crystal diffraction analysis and the structures of briaranes 2 and 3 were elucidated by using spectroscopic methods. Additionally, anti-inflammatory analysis showed that briarane 3 suppressed the iNOS and COX-2 levels, in LPS-stimulated RAW264.7 cells.



中文翻译:

叶草Brearea sp的新三羟基呋喃二烯二萜类化合物

化学研究从超临界CO 2提取的八叶树被鉴定为Briareum sp。,提取物得到已知的briarane型二萜类化合物,excavatolide B(1),和一对新的briaranes,briaviolides Y(2)和Z(3)。)。的绝对构型1用单晶衍射分析和确定briaranes的结构23通过使用光谱方法阐明。另外,抗炎分析表明,在LPS刺激的RAW264.7细胞中,braarane 3抑制了iNOS和COX-2的水平。

更新日期:2019-11-10
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