Chemical investigation of the extract from the supercritical CO₂ extraction of an octocoral identified as Briareum sp., afforded a known briarane-type diterpenoid, excavatolide B (1), and a pair of new briaranes, briaviolides Y (2) and Z (3). The absolute configuration of 1 was determined by a single-crystal diffraction analysis and the structures of briaranes 2 and 3 were elucidated by using spectroscopic methods. Additionally, anti-inflammatory analysis showed that briarane 3 suppressed the iNOS and COX-2 levels, in LPS-stimulated RAW264.7 cells.

中文翻译：

---

八叶草Brearea sp的新三羟基呋喃二烯二萜类化合物

化学研究从超临界CO ₂提取的八叶树被鉴定为Briareum sp。，提取物得到已知的briarane型二萜类化合物，excavatolide B（1），和一对新的briaranes，briaviolides Y（2）和Z（3）。）。的绝对构型1用单晶衍射分析和确定briaranes的结构2和3通过使用光谱方法阐明。另外，抗炎分析表明，在LPS刺激的RAW264.7细胞中，braarane 3抑制了iNOS和COX-2的水平。